At what point do physical dependence and symptoms typically develop in addiction?

Physical dependence and its accompanying symptoms generally develop after prolonged usage of drugs. This progression occurs because the body adjusts to the continued presence of the substance, leading to changes in how the body functions. Over time, the nervous system and other physiological systems adapt to the drug, and when the drug is not present, withdrawal symptoms often emerge as the body struggles to regain its homeostasis.

This phenomenon highlights the chronic nature of addiction, as it reflects the body's reliance on the substance for normal functioning. Initial use does not lead to physical dependence, as the body has not yet undergone changes that require the substance to operate normally. Minimal or occasional use typically does not provide enough exposure for the body to develop the adaptations necessary for dependence. Additionally, while psychological trauma may influence the likelihood of developing an addiction, it does not directly cause the physiological changes associated with physical dependence. Thus, the correct answer underscores the relationship between the duration of substance use and the development of physical dependence.